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The CDC is an operating agency of the Department of Health and Human Services that serves as the nation’s leading public health institution. The CDC’s primary mission is to protect public health and safety through the control and prevention of diseases, injury, and disability. Through its Community Transformation Grant (CTG) program, the CDC has invested more than $200 million annually in programs to promote safe and healthy neighborhood environments since 2011. As of 2015, the CTG program has been reorganized and reassigned to the Prevention and Public Health Fund, established through the Affordable Care Act. This program continues to be the primary funding source for local initiatives that address social determinants of health.